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Can the taste of a guy's semen indicate if he has an STD?

The taste of a guy's semen is not an indication of whether or not he has a sexually transmitted infection.

But that does not mean that oral sex is risk-free. Although the risks of infection are generally quite a bit lower with unprotected oral sex than they are with unprotected vaginal or anal intercourse, using a barrier during oral sex can further decrease those risks. For safer oral sex, using a condom to cover the penis, or a Glyde dam or plastic wrap to cover the vulva or anus, reduces the risk of infection.

By the way, sometimes various foods, certain medications, smoking, and alcohol can affect the way that semen tastes. There's also a wide range of textures, odors, and tastes of "normal" and healthy semen, regardless of foods, medication, and drugs.